Metabolic Flux Analysis Webinar | November 9 | Sponsored by CIL
Use of Stable Isotopes in Metabolic Flux Analysis (MFA) Studies and How the MFA Results Are Benefiting the Biomanufacturing Industry
Daniel Benjamin | Chief Scientific Officer | Metalytics
Abstract: Metabolic flux analysis (MFA) is the science of using stable isotopes to elucidate both the route of metabolism as well as the rate of metabolism. In this presentation we will demonstrate how stable isotopes are used in MFA studies with a description of the data that is collected, processed, and converted into actionable information for the biomanufacturing industry. We will present three different case studies demonstrating what knowledge was gained and used to improve productivity. We will also highlight the ability to use this stable isotope-derived MFA data to train a machine learning model that enables the rapid and accurate prediction of metabolic fluxes with limited experimental data.
Stable isotopes are crucial for calculating the precise rate and route of metabolite flow within cells using a technology called metabolic flux analysis (MFA)
Metalytics has successfully used this stable isotope-enabled MFA data to improve the productivity of biomanufacturing
Metalytics is currently using this MFA data to train a digital twin that can rapidly and accurately predict metabolic flux with limited experimental data
A transcript of this presentation in English is available here.