Neurotransmitters
Neurotransmitters are small chemicals in the central nervous system that modulate and regulate brain function. Signals are relayed from neuron to neuron by release, upon stimulation, from a synaptic vesicle into a space where it can bind to a receptor. These molecules can be grouped into several classes, such as amino acids and their derivatives (e.g., g-aminobutyric acid, glutamate) and biogenic amines (e.g., dopamine, epinephrine, serotonin). MS analysis of neurotransmitters in human biosamples, such as urine, is a clinically relevant area as they mediate homeostatic function, modulate neural activity, and have been correlated to the pathogenesis of neurodegenerative diseases (e.g., Alzheimer’s). CIL offers an array of stable isotope-labeled neurotransmitters. These products are available in their solution and/or neat form.
Related Resource
Stable Isotope Standards for Mass Spectrometry