Metabolism

Researchers employ stable isotope techniques to study a wide variety of metabolic disorders and diseases including Alzheimer’s, Parkinson’s, cancer, diabetes, and obesity. Isotopes are most commonly used in metabolism research as tracers to quantify biochemical or metabolic reactions in vivo. They can be used to study metabolic pathways, determine biomarkers, test the effects of a drug, and develop metabolic profiles of biological systems in a particular state.

Product Grades

CIL provides additional testing to many of our products as a service to our customers. The documents below describe the nature of these products, the different levels of control applied to them, and the Enhanced Technical Data Package that is available for some products.

Stable Isotope-Labeled Products for Metabolic Research 

➤ Stable Isotope Standards for Mass Spectrometry
➤ Cancer Metabolism and Related Research
➤ Amino Acid Indicators and Protein Turnover
➤ Stable Isotope Tracing in Cancer Metabolism
➤ The Impact of Stable Isotope Tracers on Metabolic Research 
➤ Research Use of CIL Products
➤ Product Quality Designations
➤ Enhanced Data Package (EDP)

Application Notes
➤ Pathway-Targeted Metabolomic Analysis in Oral/Head and Neck Cancer Cells Using Ion Chromatography-Mass Spectrometry
➤ Analysis of Whole-Body Branched-Chain Amino Acid Metabolism in Mice Utilizing 20% Leucine ¹³C₆ and 20% Valine ¹³C₆ Mouse Feed 
➤ Fluxing Through Cancer: Tracking the Fate of ¹³C-Labeled Energy Sources Glucose and Glutamine in Cancer Cells and Mouse Tumors

Amino Acids view all

Carbohydrates view all

Steroids and Hormones view all

Fatty Acids view all

Other Tracers

MRI/MRS view all

Hyperpolarization

¹³C Probes view all

Deuterated Metabolic Imaging (DMI)

Water view all

Frequently Asked Questions

When are CIL’s -MPT products tested for microbiological content? They are tested in the bulk form at release. Subsequent aliquots are not retested and guaranteed upon receipt of order. Microbiological testing does not imply suitability for any intended use.

What organisms does the microbiological testing apply to? The –MPT products are tested for S. aureus, P. aeruginosa, E. coli, Salmonella sp., aerobic bacteria, yeast, mold, and for bacterial endotoxins.

What is the limit for microbiological testing? For most products, the limit is <10 cfu/g for aerobic bacteria, yeast, and mold. These products also “pass” for S. aureus, P. aeruginosa, E. coli, Salmonella sp.

What is the limit for endotoxin testing (LAL)? Most products have an LAL specification of <0.25 EU/mg, but some can be different (<0.125, <0.03, <0.01, etc). The actual LAL results are reported on the lot-specific CoA.

Can CIL perform additional tests on research grade (-0 products) or microbiological tested material (-MPT)? Yes, CIL has the capabilities to perform additional testing on most products. This should be reviewed and quoted prior to order. An additional fee may apply.

Does CIL offer products for clinical trials? Yes, CIL can produce cGMP grade material that is suitable for clinical trials. Please contact us to discuss your project.

What algal strain is used to create mixed triglycerides products? Agmenelum quadriplicatum

What algal strain is used to create mixed fatty acids products? Agmenelum quadriplicatum

What algal strain is used to create the amino acid mixes product? Agmenelum quadriplicatum

What algal strain is the whole algal cells product? Agmenelum quadriplicatum

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