Deuterated Reagents for Pharmaceuticals
CIL offers over 11,500 stable isotope-labeled products for your synthetic applications, including the manufacturing of APIs. Many labeling patterns are available for common starting materials.
For more than 40 years, CIL has offered:
• Expertise and quality service from initial quote request through delivery
• Flexibility of scale for custom and catalog products from milligram to multikilogram quantities
• cGMP capabilities for manufacturing raw materials and bulk APIs
In recent years, some pharmaceutical companies have begun to investigate deuteration of molecules that may provide advantages over their existing nondeuterated counterparts. In addition, increasing research into the potential medical benefits of new deuterated drugs is also occurring.
The potential advantages of deuterated pharmaceuticals include:
Deuterated Reagents for Pharmaceutical and Synthetic Applications
Improved metabolic profile. The improved metabolic profile may potentially reduce or eliminate unwanted side effects or undesirable drug interactions.
Improved oral bioavailability. Deuteration in some compounds has reduced the presystemic metabolism that occurs in the digestive track, allowing more of the unmetabolized drug to reach its target.
Increased half-life. Deuterated compounds can have a slower pharmacokinetic effect, extending the absorption and distribution in the body. This may decrease the number of doses a patient may require in certain time period compared to its nondeuterated counterpart.
Filters:
Product category
Isotope Label
Label Type
Isotopic Enrichment Range
Grade
Molecular Weight Range
Product Form
Product Form 2
❛❛Cambridge Isotopes has been a partner to Concert for many years. Our relationship has been successful not only because of the quality of material supplied but the accompanying service and expertise they offer. Importantly, Cambridge Isotopes is a company that works with you, not for you.❜❜
Stuart Gebbie | Director, Pharmaceutical Development, Concert Pharmaceutical
Frequently Asked Questions
What do I do if I need multiple vials or carboys when returning D2O for the D2O Recovery Program? If you have more than ~16 L you may require multiple carboys, please just ask.
When returning D2O for the D2O Recovery Program should I fill the carboy to the top? No! Fill the bulk carboy container ~80% full. Most are shipped by FedEx Air, and if full, the carboy is likely to expand and possibly rupture the container.
Example References
Di Martino, R.M.C.; Maxwell, B.D.; Pirali, T. 2023. Deuterium in drug discovery: progress, opportunities and challenges. Nat Rev Drug Discov, 2(7), 562-584. PMID: 37277503
Mullard, A. 2022. First de novo deuterated drug poised for approval. Nat Rev Drug Discov, 21(9), 623-625. PMID: 35974147
Falb, E.; Ulanenko, K.; Tor, A.; et al. 2017. A highly efficient Suzuki-Miyaura methylation of pyridines leading to the drug pirfenidone and its CD3 version (SD-560). Green Chemistry, 21. Read article
Pepper Hamilton LLP. 2017. Deuterated drugs are new chemical entities. JDSUPRA® Read more
Mullard, A. 2016. Deuterated drugs draw heavier backing. Nat Rev Drug Discov, 15(4), 219-221. PMID: 27032821
2015. Drugs that live long will prosper. The Economist Science & Technology, Sept. 5 edition. economist.com. Read article
Tung, R. 2010. The development of deuterium-containing drugs. Innovations Pharm Technol, 32(32), 24-28. Read article