Metabolites and Substrates
To aid the varying needs of metabolomic researchers, CIL offers a wide panel of unlabeled and stable isotope-labeled metabolites and substrates. These cover a multitude of classes, including carnitine/acylcarnitines, drug standards, flavonoids, organic acids and derivatives, immunosuppressants, neurotransmitters, nucleic acids and derivatives, and vitamins. The standards are available as neat or preformulated solutions, with their labeling and enrichment as noted in each compound’s description.
Related Resources
Stable Isotope-Labeled Products for Metabolic Research
Filters:
Molecular Weight Range
- 0-100 g/mol(101)
- 101-200 g/mol(261)
- 201-300 g/mol(76)
- 301-400 g/mol(39)
- 401-500 g/mol(21)
Product Form
- Individual(565)
Filters:
Molecular Weight Range
- 0-100 g/mol(101)
- 101-200 g/mol(261)
- 201-300 g/mol(76)
- 301-400 g/mol(39)
- 401-500 g/mol(21)
Product Form
- Individual(565)
Caffeine and Caffeine Metabolites
Caffeine is a psychoactive stimulant of the central nervous system. MS-based research into caffeine and its metabolites aims to better understand kinetics/metabolism among other research pursuits (e.g., health and disease). CIL offers stable isotope-labeled caffeine and a collection of isotopically labeled metabolites for basic and translational research. These research-grade materials are available in various labeling patterns and in their neat form.
Carnitine/Acylcarnitines
CIL offers a number of carnitine/acylcarnitine standards for MS/MS screening. These dried-down metabolites are available in their unlabeled and/or isotope-labeled form. Select carnitine/acylcarnitine standards have also been formulated into mixtures (isotope-labeled, NSK-B and NSK-B-G1; unlabeled, NSK-B-US and NSK-B-G1-US) and are supplied in one vial or 10-vial sets.
Dopa and Dopamine
L-Dihydroxyphenylalanine (L-DOPA or levodopa) is an amino acid that functions biologically as a metabolic precursor to the neurotransmitter dopamine (DA). L-DOPA is decarboxylated to dopamine by the enzyme DOPA decarboxylase. Due to its structural similarity to dopamine and its blood-brain accessibility, L-DOPA is a commonly administered treatment for Parkinson’s disease (PD). CIL is pleased to offer a variety of stable isotope-labeled standards of L-DOPA and dopamine for research use applications. These standards are available in their neat and/or solution form, with their unlabeled analogues also available for qualitative/quantitative research purposes.
Drug Standards
The field and scope of drug screening/analysis continues to expand worldwide. Example areas of focus include therapeutic drug monitoring, drugs of abuse, prescription monitoring, and clinical toxicology. The nature of those monitored or identified in the MS-based analysis include psychoactive drugs (e.g., benzodiazepines, cannabinoids, hallucinogens), pain-management drugs (e.g., analgesics, opiates, skeletal muscle relaxants), disorder-related treatment drugs (e.g., anticonvulsants /antiepileptics, antipsychotics), infectious disease or disease-related treatment drugs (e.g., antibiotics, antiarrhythmics), and antiviral drugs (e.g., antibiotics, anticoagulants, anti-inflammatory agents). CIL is pleased to offer a broad collection of unlabeled and stable isotope-labeled standards to aid the qualitative/quantitative analysis of drugs and their metabolites. These encompass a multitude of classes and are available as individual standards and/or class-specific mixtures in predominantly their concentrated solution form.
Immunosuppressants
Immunosuppressant drugs (ISDs) are used to suppress the immune system by triggering immune cell death or the inhibition of immune cell production. These are commonly administered to organ-transplant patients and to those afflicted with autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, and Crohn's disease). We are pleased to offer a variety of immunosuppressant drugs for use as quantitative standards in preclinical or clinical MS-based studies. Examples of immunosuppressants in our product portfolio include everolimus, methotrexate, sirolimus, and tacrolimus. These are available as stable isotope-labeled and unlabeled standards in their neat and/or solution form for research-grade applications.
α-Keto Acids
Alpha-keto acids serve critical biological functions and are involved in regulating key signaling pathways (e.g., Krebs cycle, glycolysis). To aid their research explorations, CIL offers a multitude of stable isotope-labeled a-keto acids. These metabolites are available individually as neat materials in their research and/or microbiological and pyrogen tested (MPT) grade form. A subset of these are also formulated into a dried-down mix for multiplexed quantitative analysis (see MSK-OA).
Key Metabolite Standards
CIL is pleased to provide smaller package sizes (0.1 mg) for top metabolite standards. These stable isotope-labeled compounds cover a range of classes (e.g. fatty acid and lipids, sugar and sugar phosphates, and organic acids). The new sizes provide flexibility and ease of use for MS-based metabolomics studies.