Metabolomics Standards

CIL offers an array of stable isotope-labeled standards for MS metabolomics research. These are predominantly neat, with the labeling at variable isotopic positions. The metabolite standards are available in different forms (e.g., free acid, salt) and material grades (i.e., research, microbiological and pyrogen tested – MPT). These span a breadth of metabolic classes (e.g., amino and organic acids, fatty acids and lipids, steroids and hormones, vitamins) and biochemical pathways (e.g., glycolysis, pentose phosphate, TCA cycle). They can be used for flux determination and/or relative or absolute quantification of metabolites in biological systems. Research end goals encompass biomarker assessment and therapeutic drug evaluation, among other directions.

➤ Stable Isotope Standards for Mass Spectrometry
➤ Stable Isotope-Labeled Products for Metabolic Research
➤ Stable Isotope-Labeled Products for Microbiome Research
➤ Foodomics – Standards for Identification and Quantification
➤ Stable Isotope Standards for Waters MetaboQuan-R™ Methods
➤ Small Package Sizes for Key Metabolite Standards
➤ Dimethyl Labeling Reagent Sets

Technical Notes and Researcher Perspective
➤ Importance of Stable Isotope Standards and Their Implementation in Clinical Mass Spectrometry
➤ Benefits of ¹³C vs. D Standards in Clinical Mass Spectrometry Measurements
➤ Stable Isotopes in Metabolomics and Metabolism

Stable Isotope-Labeled Products for Metabolic Research

Metabolomics Standards

Frequently Asked Questions

What is the smallest prepackaged unit size for metabolites? CIL offers a variety of key metabolite standards in 0.1 mg. That 0.1 mg represents the smallest unit size. See our Small Package Sizes flyer for a listing and reach out should this unit be required for your metabolite of interest.

Can alternate labeled metabolites be synthesized upon request? Yes, provided they can be synthesized through enzymatic and/or chemical means. Please submit your request to your local sales representative/distributor or complete the on-line Custom Synthesis form. Structure(s), desired quantities, and labeling pattern(s) (if applicable) are required. We will contact you shortly thereafter regarding its feasibility.

Liang, S.S.; Shen, P.-T.; Liang, Y.-Q.; et al. 2023. Assisted reductive amination for quantitation of tryptophan, 5-hydroxytryptophan, and serotonin by ultraperformance liquid chromatography coupled with tandem mass spectrometry. Molecules, 6(28), 4580-4589. PMID: 37375135
Apiz Saab, J.J.; Dzierozynski, L.N.; Jonker, P.B.; et al. 2023. Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis. Elife, 12, e81289. PMID: 37254839  
Sciacovelli, M.; Dugourd, A.; Jimenez, L.V.; et al. 2022. Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. Nat Commun, 13(1), 7830-7849. PMID: 36539415 
Sponagel, J.; Jones, J.K.; Frankfater, C.; et al. 2022. Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment. Med, 3(11), 792-811. PMID: 36108629 
Grima-Reyes, M.; Vandenberghe, A.; Nemazanyy, I.; et al. 2022. Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression. Sci Adv, 8(27), eabn6491. PMID: 35857457 
Pastushkova, L.K.; Goncharov, I.N.; Koloteva, M.I.; et al. 2022. Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions. Life Sci Space Res, 33, 7-12. PMID 35491032