November 2022

➤ Cardiac Myosin Filaments are Maintained by Stochastic Protein Replacement
➤ An Optimized MRM-Based Workflow of the l-Arginine/Nitric Oxide Pathway Metabolites Revealed Disease- and Sex-Related Differences in the Cardiovascular Field
➤ Continuous Oral Stable Isotope Ingestion to Measure Whole-Body Protein Turnover
➤ The Metabolism of Human Soluble Amyloid Precursor Protein Isoforms Is Quantifiable by a Stable Isotope Labeling-Tandem Mass Spectrometry Method
➤ TurnoveR: A Skyline External Tool for Analysis of Protein Turnover in Metabolic Labeling Studies
➤ Isotope Tracing in Health and Disease

May 2022

➤ Temporal Quantitative Profiling of Newly Synthesized Proteins during Aß Accumulation
➤ Human Colorectal Cancer-on-Chip Model to Study the Microenvironmental Influence on Early Metastatic Spread
➤ Fructose Reprograms Glutamine-Dependent Oxidative Metabolism to Support LPS-Induced Inflammation
➤ Utilizing Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry to Assess INLIGHT™ Derivatized N-Linked Glycans in Biological Samples
➤ A Mass Spectrometry-Based Targeted Assay for Detection of SARS-Cov-2 Antigen from Clinical Specimens
➤ Reference Materials for MS-Based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC)
➤ Principles of Stable Isotope Research – with Special Reference to Protein Metabolism

May 2020

➤ TMTpro: Design, Synthesis, and Initial Evaluation of a Proline-Based Isobaric 16-Plex Tandem Mass Tag Reagent Set
➤ Domain-Specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry
➤ A Novel Stable Isotope Tracer Method to Simultaneously Quantify Skeletal Muscle Protein Synthesis and Breakdown
➤ Impact of Enteral Arginine Supplementation on Lysine Metabolism in Humans: A Proof-of-Concept for Lysine-Related Inborn Errors of Metabolism
➤ Identification of Bioactive Metabolites Using Activity Metabolomics

October 2019

➤ SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1
➤ Preclinical Studies on Metal-based Anticancer Drugs as Enabled by Integrated Metallomics and Metabolomics
➤ Leucine Co-ingestion Augments the Muscle Protein Synthetic Response to the Ingestion of 15 g Protein Following Resistance Exercise in Older Men
➤ Assessment of Methylcitrate and Methylcitrate-to-Citrate Ratio in Dried Blood Spots as Biomarkers for Inborn Errors of Propionate Metabolism
➤ Metabolomics and Isotope Tracing

May 2019

➤ Assessment of NAD+ Metabolism in Human Cell Cultures, Erythrocytes, Cerebrospinal Fluid and Primate Skeletal Muscle
➤ Mitochondrial Fusion Supports Increased Oxidative Phosphorylation During Cell Proliferation
➤ Essential Amino Acid-enriched Meal Replacement Promotes Superior Net Protein Balance in Older, Overweight Adults
➤ Traceability to a Primary Reference Measurement Procedure (ID-LCMS): A Key Step in Validating the Clinical Accuracy and Safety of Hospital Blood Glucose Monitoring Systems
➤ NMR- and MS-based Stable Isotope-resolved Metabolomics and Applications in Cancer Metabolism

December 2018

➤ Lysine Propionylation Boosts Proteome Sequence Coverage and Enables a “Silent SILAC” Labeling Strategy for Relative Protein Quantification
➤ ¹³C-Labeled Yeast as Internal Standard for LC-MS/MS and LC High Resolution MS Based Amino Acid Quantification in Human Plasma
➤ Glutamine-Derived 2-Hydroxyglutarate Is Associated with Disease Progression in Plasma Cell Malignancies
➤ Hepatic Ketogenic Insufficiency Reprograms Hepatic Glycogen Metabolism and the Lipidome
➤ A Targeted Metabolomics Approach for Clinical Diagnosis of Inborn Errors of Metabolism
➤ A Guide to ¹³C Metabolic Flux Analysis for the Cancer Biologist
➤ SNMMI Image of the Year Is the Endocyte 177 Lu PSMA-617

May 2018

➤ Multiplexed Proteome Analysis with Neutron-Encoded Stable Isotope Labeling in Cells and Mice
➤ A Mass Spectrometry-based Proteomic Analysis of Homer2-interacting Proteins in the Mouse Brain
➤ Two Complementary Reversed-Phase Separations for Comprehensive Coverage of the Semipolar and Nonpolar Metabolome
➤ METLIN: A Technology Platform for Identifying Knowns and Unknowns
➤ Noninvasive Liquid Diet Delivery of Stable Isotopes into Mouse Models for Deep Metabolic Network Tracing
➤ A Timeline of Stable Isotopes and Mass Spectrometry in the Life Sciences

October 2017

➤ HILAQ: A Novel Strategy for Newly Synthesized Protein Quantification
➤ Multiplexed MRM-Based Protein Quantitation Using Two Different Stable Isotope-Labeled Peptide Isotopologues for Calibration
➤ Anion-Exchange Chromatography Coupled to High Resolution Mass Spectrometry: A Powerful Tool for Merging Targeted and Non-Targeted Metabolomics
➤ Metabolite Spectral Accuracy on Orbitraps
➤ How Close Are We to Complete Annotation of Metabolomes?
➤ Plasmonic Silver Nanoshells for Drug and Metabolite Detection

April 2017 

➤ SWATH-based Proteomics Identified Carbonic Anhydrase 2 as a Potential Diagnosis Biomarker for Nasopharyngeal Carcinoma
➤ Serotonin Biosynthesis as a Predictive Marker of Serotonin Pharmacodynamics and Disease-Induced Dysregulation
➤ ¹³C Metabolic Flux Analysis of Acetate Conversion to Lipids by Yarrowia lipolytica 
➤ Comparative Analysis of INLIGHT™-labeled Enzymatically Depolymerized Heparin by Reverse-phase Chromatography and High-performance Mass Spectrometry
➤ Historical and Contemporary Stable Isotope Tracer Approaches to Studying Mammalian Protein Metabolism

November 2016

➤ Multiplexed MRM-Based Assays for the Quantitation of Proteins in Mouse Plasma and Heart Tissue
➤ Optimal Tracers for Parallel Labeling Experiments and ¹³C Metabolic Flux Analysis: A New Precision and Synergy Scoring System
➤ N-linked Glycosite Profiling and Use of Skyline as a Platform for Characterization and Relative Quantification of Glycans in Differentiating Xylem of Populus trichocarpa 
➤ Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics
➤ Quality Management in Clinical Application of Mass Spectrometry Measurement Systems

July 2016

➤ Determining Synthesis Rates of Individual Proteins in Zebrafish Danio rerio with Low Levels of a Stable Isotope Labelled Amino Acid
➤ NeuCode Proteomics and Bap1 Regulation of Metabolism
➤ Stable Isotope Labeling of Algal Biomass Carbohydrates
➤ Biochemical Pathways Affected by Mitochondrial Stress
➤ MS-based Quantitative Plasma Proteomics

April 2016

➤ Immobilized Metal Affinity Chromatography Coupled to Multiple Reaction Monitoring Enables Reproducible Quantification of Phosphosignaling
➤ Discovery of Serum Protein Biomarkers in the mdx Mouse Model and Cross-Species Comparison to Duchenne Muscular Dystrophy Patients
➤ Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery
➤ Gluconeogenesis and Glycogenolysis Measurement Review
➤ Recommendations for Peptides Used In Mass Spectrometry Assays
➤ Proteomic Maps of Breast Cancer Subtypes

November 2015

➤ Relative Quantification and Higher-Order Model of Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples
➤ A Standardized Kit for Automated Quantitative Assessment of Candidate Protein Biomarkers in Human Plasma
➤ Proteomic Analysis of pRb Loss Highlights a Signature of Decreased Mitochondrial Oxidative Phosphorylation
➤ A Roadmap for Interpreting ¹³C Metabolite Labeling Patterns from Cells
➤ Cancer Cell Metabolism Unique Features Inform New Therapeutic Opportunities
➤ LC-MS-based Quantification of Intact Proteins: Perspective for Clinical and Bioanalytical Applications

December 2023

➤ Dioxin and Furan Standard Mixtures Made for GC-MS/MS Methods
➤ 6PPD-Quinone
➤ Volatile Organic Compounds in Wildfire Smoke
➤ 29 PFAS Compounds Being Monitored in Public Water Systems Under UCMR 5
➤ Chlorates and Bromates in Food and Water
➤ Mitigation Measures for Malathion

July 2023

➤ Dechlorane Plus, UV-328, and Methoxychlor Face Global Ban Under Stockholm Convention
➤ US EPA Proposes Rule to Reduce Emissions from Chemical Plants
➤ PCNs in Environmental and Human Exposure Studies
➤ CIL’s PAH Standards – For Food, Environmental, and Human Exposure Analysis

April 2023

➤ New Regulations in North America and Europe Increase Restrictions on More PFAS Compounds
➤ Flame Retardants – Legacy and New Use Compounds
➤ Pharmaceutical and Personal Care Products
➤ France Ends Exemption Use of Neonicotinoids

December 2022

➤ US EPA Withdraws Interim Registration Review Decision for Glyphosate
➤ CIL – The World’s Leading Producer of Stable Isotopes
➤ PFAS Detected in Pet Food Packaging

October 2022

➤ Dawn Mantz Joins the CIL Environmental Sales Team!
➤ US EPA Plans to Enforce Restrictions on Atrazine Use
➤ US FDA Limits Certain Phthalates in Food Packaging Materials
➤ Update on Halogenated Compounds from EURL

July 2022

➤ New ¹³C₁₂-6PPD-Quinone Standard for Enhanced Analysis
➤ Ethylene Oxide and 2-Chloroethanol in Food
➤ Potassium Bromate Additive – Potential Carcinogen in Packaged Baked Goods
➤ FDA to Evaluate and Reconsider Bisphenol A Restrictions in Food Packaging
➤ US EPA Proposes Ban on Diuron on Food

April 2022

➤ New Pyrethroid Metabolite Standards – Now Available!
➤ Europe Proposes Large Reduction in Use of Bisphenol A
➤ UK Approves Emergency Use Authorization of Thiamethoxam in Sugar Beets

December 2021

➤ Neonicotinoids of Particular Concern and Results from the 2019 European Union Report on Pesticide Residues in Food
➤ New Nitrosamine Mixes – US EPA Method 521 and More!
➤‘Isotope’ – It May be Our Middle Name, but it Is not Our Only Business

October 2021

➤ Cannabis Testing Standards – Now Available from CIL!
➤ Foodomics – Standards for Metabolic Biomolecules and Food Contaminants
➤ Ethylene Oxide and 2-Chloroethanol Analytical Standards
➤ US EPA Method 1628 – New Method Posted for the Analysis of 209 PCB Congeners

June 2021

➤ Biomonitoring – Analytical Standards for Human Exposure Analysis
➤ Dioxin/Furan Mixtures for Food/Feed and GC-MS/MS Analysis
➤ Nitrosamine Standards Update – NPIP, NDBA, and NMEA Now Available!
➤ New Product Release – Glufosinate
➤ Chlorpyrifos Regulation Update

October 2019

➤ BPS Joins BPA Ban in Thermal Paper
➤ Human Biomonitoring Initiative Takes Flight in Europe
➤ Halogenated Flame Retardant Ban in EU
➤ Update on Nitrosamine Standards – NMBA Now Available

August 2019

➤ Regulatory Actions by the EU and US EPA on Neonicotinoids Take Effect
➤ Analyzing Cyanotoxins in Surface Water and Drinking Water
➤ Proposed Limit on Perchlorate in Drinking Water

April 2019

➤ Move to Restrict Siloxanes in the European Union
➤ Blood Pressure Medicine Recalls Expanded Due to Presence of Nitrosamines
➤ Environmental Group Updates

December 2018

➤ Hervé Mohr Joins the CIL Environmental Team!
➤ New Developments with Exposomics Initiatives
➤ Blood Pressure Medications Recalled Due to the Presence of Nitrosamines
➤ Chlorpyrifos Banned by EPA via Court Order

August 2018

➤ Chlorate Standards for Food and Water Testing
➤ Analyzing Cyanotoxins Using LC-MS/MS with 15N-Stable Isotope-Labeled Internal Standards
➤ Dicamba and Metabolites
➤ Per- and Polyfluoroalkyl Substances (PFAS) Update
➤ Phthalates and Phthalate Replacement Products

April 2017

➤ New Catalog Announcement
➤ New Pyrethroids Available at CIL
➤ CIL and Italy...A Relationship that Began 40 Years Ago
➤ Chlorpyrifos Under Review

August 2016

➤ 1,2,3-Trichloropropane (1,2,3-TCP) in Drinking Water
➤ Acaricides in Common Flea and Tick Repellants
➤ Glyphosate Use and Regulations
➤ New POPs Chemicals Added to the Stockholm Convention in 2015

April 2016

➤ Neonicotinoid Pesticides
➤ Parabens
➤ Introducing CIL's New Catalog, Standards for Environmental, Food, Water, and Exposure Analysis
➤ 2016 International Interlaboratory Study on Fish Reference Materials

October 2015

➤ Curious (but correct!) Naming of CIL's Isotopically Labeled Ethynylestradiol (EE2) Standard
➤ New PCN Standard (PCN Update)

July 2015

➤ Sodium Monofluoroacetate
➤ Fipronil
➤ New Polychlorinated Naphthalenes (PCNs)

January 2015

➤ Tobacco Specific Nitrosamines
➤ Toxaphene
➤ Phthalates

August 2014

➤ Dechlorane-602
➤ Bisphenol A (BPA)
➤ Calculating Concentrations of Free Acid or Base from Salt Form

October 2013

➤ Nonylphenol Added to List of Toxic Chemicals
➤ Human Biomonitoring: Attogram Level Sensitivity and Consequences for Analytical Standards Purity
➤ New Polychlorinated Naphthalene Standards
➤ Emerging Pesticides: Trifluralin

June 2013

➤ Using ¹³C-Labeled Standards and ID-HRMS for Low-Level PAH Determination in Water and Tissue Samples
➤ Triclosan in the News
➤ Interested in PAHs and PAH Metabolites?

June 2012

➤ CDC’s National Report on Human Exposure to Environmental Chemicals
➤ Reconstitutable Solutions
➤ EPA Perchlorate Regulations
➤ PAH Metabolites

January 2012

➤ Emerging Contaminants in the Great Lakes
➤ Determination of Glyphosate and AMPA
➤ EPA Report on Monitoring Parlar Compounds

August 2011

➤ Plasticizers in Food Are Now Substances of Higher Concern
➤ Bisphenol A Under Increased Scrutiny for Health Effects
➤ Endosulfans Added to Stockholm Convention POPs
➤ No Quantitation without Representation!

April 2011

➤ New Cod Liver Oil Interlab Study Results
➤ “High Purity” PCB Standards from CIL
➤ Atrazine and Atrazine Metabolites

June 2010

➤ EPA Targets Cancer-Causing Contaminants
➤ Stockholm Convention Adds New POPs
➤ CIL Dioxin and Furan Standards Produced under ISO Guide 34 and ISO/IEC 17025